Gestational pemphigoid
نویسندگان
چکیده
Gestational pemphigoid is a rare pruritic bullous pregnancy associated dermatosis caused by autoantibodies against placental and dermal collagen XVII. Clinically, it is characterized by severe pruritus and blisters on abdominal skin and extremities. Immunofluorescence analysis of perilesional skin is used in the diagnostics and maternal serum BP180-levels reflect the disease activity. Topical steroids and antihistamins usually relieve mild symptoms, but in severe cases oral corticosteroid is the drug-of-choice. Spontaneous recovery is common after parturition but this disease typically recurs in the following pregnancies. Due to the associated risk of prematurity and fetal growth restriction, prenatal monitoring jointly by a dermatologist and an obstetrician is recommended.
منابع مشابه
Gestational pemphigoid: placental morphology and function.
Gestational pemphigoid (PG), a very rare pregnancy-associated bullous dermatosis, is associated with adverse pregnancy outcome (miscarriage, preterm delivery, foetal growth restriction). The major antigen in PG is collagen XVII (BP180). PG autoantibodies cross-react with collagen XVII in the skin and have been suggested to cause placental failure. On this basis, we evaluated clinical outcome an...
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Pemphigoid diseases are a group of well defined autoimmune disorders. The most common of these diseases is bullous pemphigoid, which. Abstract Bullous pemphigoid BP is a blistering skin disease. Plex and includes bullous pemphigoid, pemphigoid gestationis, mucous.Bullous pemphigoid BP is an autoimmune subepidermal bullous dermatosis defined. Http:www.orpha.netdatapathoGBukBullousPemphigoid.pdf....
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Background: Pregnancy-specific dermatoses represent a group of pruritic skin diseases unique to pregnancy and the most common types are polymorphic eruption of pregnancy and pemphigoid gestationis. It is difficult to obtain a histopathological diagnosis for polymorphic eruption of pregnancy and pemphigoid gestationis in the lack of immunofluorescence because of their similar clinical presentati...
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عنوان ژورنال:
دوره 9 شماره
صفحات -
تاریخ انتشار 2013